M-Kast 10mg 14pcs

Indications

M-Kast 10 is a prescription medication used to prevent asthma and treat allergy symptoms such as sneezing and runny nose. It eases breathing by reducing inflammation in the airways. M-Kast 10 can be taken with or without food, but it is best taken at the same time. If you have exercise-induced asthma, it is recommended that you take it 2 hours before exercise. It should be regarded as medical advice.

Pharmacology

M-Kast 10 is a leukotriene receptor antagonist that works by inhibiting the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are arachidonic acid metabolism products that are released by a variety of cells, including mast cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupancy have been linked to the pathophysiology of asthma and allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, all of which contribute to asthma symptoms.

Dosage

Adults and adolescents (15 and up)-

10 mg/day for Asthma and Allergic Rhinitis

10 mg/day for exercise-induced bronchoconstriction

Children (6 to 14 years old)-

5 mg/day for Asthma and Allergic Rhinitis

5 mg/day for exercise-induced bronchoconstriction

Patients aged 6 months to 5 years-

4 mg/day for Asthma and Allergic Rhinitis

Exercise-Induced Bronchoconstriction: Avoid.

Patients with asthma and allergic rhinitis should take only one dose daily in the evening. For prevention of Acute prevention of Exercise-Induced Bronchoconstriction, a single dose should be taken at least 2 hours before exercise.

Administration

Route of administration: 

• Oral. Montelukast may be taken with or without food or as directed by the physician.
• If you have exercise-induced asthma, take M-Kast 10 2 hours before exercising.

Interaction

When combined with theophylline, prednisone, prednisolone, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative-hypnotics, nonsteroidal anti-inflammatory agents, benzodiazepines, decongestants, oral contraceptives, and Cytochrome P450 (CYP) enzyme inducers, no dose adjustment is required. Bioavailability and other conditions were not significantly observed with food and other conditions.

Contraindications

M-Kast 10 is contraindicated in patients who are hypersensitive to any component of this product.

Side Effects

Diarrhea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, and upper respiratory tract infection are all common symptoms.

Anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, and sleep disorders are uncommon.

Angioedema, impaired concentration, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal ideation, tremor are all rare.

Pregnancy & Lactation

There are no adequate and well-controlled studies on pregnant women. M-Kast 10 should be used during pregnancy only if clearly needed. Montelukast is excreted in breast milk. So caution should be exercised when M-Kast 10 is given to a nursing mother.

Precautions & Warnings

M-Kast 10 is not indicated for use in reversing bronchospasm in acute asthma attacks, including status asthmatic. Neuropsychiatric events include agitation, hostility, anxiousness, depression, disorientation, disturbance in attention, dream abnormalities, hallucinations, insomnia, irritability, memory impairment, restlessness, somnambulism, suicidal thinking and behavior (including suicide), and tremor.

Storage Conditions

Store in a cool & dry place below 30°C, and protect from light & moisture. Keep out of reach of children.